Interferons: Signaling, antiviral and viral evasion
نویسندگان
چکیده
منابع مشابه
Antiviral defense: interferons and beyond
Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regar...
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Interferon (IFN) responses, mediated by a myriad of IFN-stimulated genes (ISGs), are the most profound innate immune responses against viruses. Cumulatively, these IFN effectors establish a multilayered antiviral state to safeguard the host against invading viral pathogens. Considerable genetic and functional characterizations of mammalian IFNs and their effectors have been made, and our unders...
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In response to a viral infection, the host innate immune response is activated to up-regulate gene expression and production of antiviral cytokines. Conversely, viruses have evolved intricate strategies to evade and exploit host immune signaling for survival and propagation. Viral immune evasion, entailing host defense and viral evasion, provides one of the most fascinating and dynamic interfac...
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1 Experimental Therapeutics Centre, Agency for Science, Technology, and Research, Singapore, 2 Programme in Emerging Infectious Diseases, Duke-NUSMedical School, Singapore, 3 Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 4 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 5 Singapore-MIT...
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Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...
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ژورنال
عنوان ژورنال: Immunology Letters
سال: 2009
ISSN: 0165-2478
DOI: 10.1016/j.imlet.2008.11.002